Differential mucosal gene expression modulates the development of murine colitis

نویسندگان

  • Zhiping Liu
  • Michael J. Wannemuehler
  • Randy E. Sacco
  • Jesse M. Hostetter
  • Douglas E. Jones
  • Eileen L. Thacker
  • Gavin Liu
چکیده

46 Introduction 47 Material and Methods 48 Results 50 Discussion 63 References 66 Supplemental Data 72 CHAPTER 3. EFFECTS OF Helicobacter bilis COLONIZATION ON MURINE COLITIS INDUCED BY DEXTRAN SODIUM SULFATE 80 Abstract 80 Introduction 81 Material and Methods 83 Results 87 Discussion 101 References 105 Supplemental Data 11080 Introduction 81 Material and Methods 83 Results 87 Discussion 101 References 105 Supplemental Data 110 CHAPTER 4. ORAL TREATMENT WITH HYPOXOSIDE AMELIORATES Brachyspira hyodysenteriae INDUCED MURINE COLITIS 114 Abstract 114 Introduction 115 Material and Methods 117114 Introduction 115 Material and Methods 117

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

BACKGROUND Therapeutic gene transfer is currently being evaluated as a potential therapy for inflammatory bowel disease. This study investigates the safety and therapeutic benefit of a locally administered lentiviral vector encoding murine interleukin-10 in altering the onset and relapse of dextran sodium sulfate induced murine colitis. METHODS Lentiviral vectors encoding the reporter genes f...

متن کامل

DIFFERENTIAL EXPRESSION OF SURFACE MARKERS CD45RB AND CD44 ON MURINE CD8+ CELLS

Considering the emerging importance of phenotypic markers as indicators of cell function and differentiation, we studied patterns ofCD44 and CD45RB expression in CD8+ murine T cells with prior exposure to antigen or staphylococcal enterotoxin B ( SEB ). Following in vivo priming with two purified protein derivatives (one from a virulent WHO strain and the other from an avirulent strain), T ...

متن کامل

A novel Toll-like receptor 4 antagonist antibody ameliorates inflammation but impairs mucosal healing in murine colitis.

Dysregulated innate immune responses to commensal bacteria contribute to the development of inflammatory bowel disease (IBD). TLR4 is overexpressed in the intestinal mucosa of IBD patients and may contribute to uncontrolled inflammation. However, TLR4 is also an important mediator of intestinal repair. The aim of this study is to examine the effect of a TLR4 antagonist on inflammation and intes...

متن کامل

Maternal methyl-donor supplementation induces prolonged murine offspring colitis susceptibility in association with mucosal epigenetic and microbiomic changes.

Developmental epigenetic changes, such as DNA methylation, have been recognized as potential pathogenic factors in inflammatory bowel diseases, the hallmark of which is an exaggerated immune response against luminal microbes. A methyl-donor (MD) diet can modify DNA methylation at select murine genomic loci during early development. The components of the MDs are routinely incorporated into prena...

متن کامل

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.

Mucosal epithelial cells are uniquely equipped to maintain barrier function even under adverse conditions. Previous studies have implicated hypoxia in mucosal tissue damage resulting from both acute and chronic inflammation. Given the importance of the transcriptional regulator hypoxia-inducible factor-1 (HIF-1) for adaptive hypoxia responses, we hypothesized that HIF-1 may serve as a barrier-p...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016